This article is from Molecular Vision, volume 18.AbstractPurpose: To investigate cadmium chloride cytotoxicity in human lens epithelial cells as well as the mode of cell death and its mechanism. Methods: Cultured human lens epithelial cells were challenged with cadmium chloride. Morphological changes of human lens epithelial cells caused by cadmium chloride exposure were evaluated by microscope. Cell viability was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-dipheny tetrazolium bromice... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339033
byPenha, Alexandra Marcha; Burkhardt, Eva; Schaeffel, Frank; Feldkaemper, Marita P.
This article is from Molecular Vision, volume 18.AbstractPurpose: Intravitreal insulin has been shown to be a powerful stimulator of myopia in chickens, in particular if the retinal image is degraded or defocused. In most tissues, the insulin receptor activates two main signaling pathways: a) the mitogen-activated protein kinase (MAPK) cascade (e.g., mitogen-activated protein kinasem kinase [MEK] and extracellular regulated kinase [ERK]) and b) the phosphatidylinositol 3-kinase (PI3K)/protein... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482168
byRosen, Richard B.; Hu, Dan-Ning; Chen, Min; McCormick, Steven A.; Walsh, Joseph; Roberts, Joan E.
This article is from Molecular Vision, volume 18.AbstractPurpose: Recently, we reported finding that circulating melatonin levels in age-related macular degeneration patients were significantly lower than those in age-matched controls. The purpose of this study was to investigate the hypothesis that melatonin deficiency may play a role in the oxidative damage of the retinal pigment epithelium (RPE) by testing the protective effect of melatonin and its receptor antagonist on RPE cells exposed to... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388983
This article is from Molecular Vision, volume 19.AbstractPurpose: Diabetic retinopathy (DR) is a leading cause of vision loss in working-age people. To retard the development and progression of retina lesions, effective therapeutic strategies directed toward key molecular targets are desired. Phlorizin is effective in treating diabetic complications, but little is known about functional protein changes that may mediate its actions. The aim of this study was to identify retinal proteomic... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626294
This article is from Molecular Vision, volume 20.AbstractPurpose: Vegetable polyphenols (bioflavonoids) have been suggested to represent promising drugs for treating cancer and retinal diseases. We compared the effects of various bioflavonoids (epigallocatechin-3-gallate [EGCG], luteolin, apigenin, myricetin, quercetin, and cyanidin) on the physiological properties and viability of cultured human retinal pigment epithelial (RPE) cells. Methods: Human RPE cells were obtained from several donors... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945811
This article is from Molecular Vision, volume 20.AbstractPurpose: Oxidative and nitrosative stress underlies cataractogenesis, and therefore, various antioxidants have been investigated for anticataract properties. Several vitamin E analogs have also been studied for anticataract effects due to their antioxidant properties; however, the anticataract properties of tocotrienols have not been investigated. In this study, we investigated the effects of topically applied tocotrienol on the onset and... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057512
byFu, Shuhua; Zhu, Meili; Wang, Changyun; Le, Yun-Zheng
This article is from Molecular Vision, volume 20.AbstractPurpose: To dissect gene functions in the retinal pigment epithelium (RPE), we previously generated a tetracycline-inducible RPE-specific Cre mouse line. Although this Cre mouse line was useful for several conditional gene targeting studies that were conducted by different laboratories, its potential has not been fully exploited, presumably due to a lack of knowledge or procedure for inducing Cre expression appropriately in this mouse... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984040
This article is from Molecular Vision, volume 18.AbstractPurpose: To investigate the efficacy of plasmin and sulfur hexafluoride (SF6) on the vitreoretinal junction, as well as the long-term safety in the eye and effect on the recipient’s general health after application in the eye. Methods: The study design included four groups of rabbits with three animals in each group. Group 1 received an intravitreal injection (IVI) of plasmin and SF6 in the right eye; group 2 received an IVI of plasmin... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462594